⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30658033 | 0.92 | MAPT (0.31) | — | |
| SCHEMBL26804410 | 0.90 | PBRM1 (0.33) | — | |
| SCHEMBL26654032 | 0.88 | VHL (0.35) | — | |
| SCHEMBL26653886 | 0.84 | VHL (0.43) | — | |
| SCHEMBL26653883 | 0.84 | VHL (0.43) | — | |
| SCHEMBL26804406 | 0.82 | MAPT (0.32) | — | |
| SCHEMBL31294071 | 0.78 | — | — | |
| SCHEMBL30666267 | 0.78 | MAPT (0.31) | — | |
| SCHEMBL26683340 | 0.78 | MAPT (0.31) | — | |
| SCHEMBL31293716 | 0.78 | RAB9A (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250302832-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC (US) | 2025-10-02 | — | — | US | disclosed |
| CN-120035593-A | Pyrazine derivatives and uses thereof | 福宏治疗公司 | 2025-05-23 | — | — | CN | disclosed |
| EP-4522279-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |