Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.38 |
| ▸ | ITK | Q08881 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270784 | 0.89 | MAPK3 (0.47) | EGFRJAK3AURKAMAPK3MAPK1 | |
| SCHEMBL10261580 | 0.84 | EGFR (0.45) | EGFRJAK3AURKAMAPK3MAPK1 | |
| SCHEMBL13868411 | 0.84 | SYK (0.48) | EGFRJAK3AURKAMAPK3PKMYT1 | |
| SCHEMBL12111172 | 0.83 | EGFR (0.60) | EGFRJAK3SYKBTKITK | |
| SCHEMBL12279068 | 0.79 | ALDH1A1 (0.44) | AURKAMAPK3MAPK1MAP2K1BTK | |
| SCHEMBL263570 | 0.77 | ALDH1A1 (0.42) | AURKAMAPK3MAPK1MAP2K1SCN9A | |
| SCHEMBL12320917 | 0.74 | TTBK1 (0.42) | EGFRJAK3AURKAMAPK3MAPK1 | |
| SCHEMBL13868406 | 0.74 | EGFR (0.53) | EGFRJAK3AURKASYKBTK | |
| SCHEMBL270260 | 0.74 | AURKA (0.45) | AURKAMAPK3PKMYT1 | |
| SCHEMBL270219 | 0.73 | TP53 (0.43) | AURKAMAPK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133900-B2 | Use of bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2012-03-13 | — | — | US | disclosed |