⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10550374 | 0.98 | — | — | |
| SCHEMBL11381058 | 0.84 | KMT2A (0.56) | — | |
| SCHEMBL8962578 | 0.82 | CYP2D6 (0.53) | — | |
| SCHEMBL9645566 | 0.80 | HTT (0.59) | — | |
| SCHEMBL7348336 | 0.80 | CYP2D6 (0.51) | — | |
| SCHEMBL124180 | 0.80 | CYP2D6 (0.51) | — | |
| SCHEMBL7063746 | 0.80 | CYP2D6 (0.48) | — | |
| SCHEMBL14492443 | 0.76 | CYP2D6 (0.43) | — | |
| SCHEMBL8056773 | 0.76 | CYP2D6 (0.43) | — | |
| Hydrochloric Acid SCHEMBL9701373 | 0.74 | CA12 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267711-A1 | METHOD OF ENHANCING CELLULAR PRODUCTION OF MOLECULAR CHAPERONE, HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE CHAPERONE PRODUCTION AND THE PREPARATION THEREOF | CYTRX CORPORATION (US) | 2010-10-21 | — | — | US | disclosed |
| US-7148239-B2 | Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof | CYTRX CORPORATION (US) | 2006-12-12 | — | — | US | disclosed |
| US-20040019103-A1 | Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof | BIOREX RESEARCH & DEVELOPMENT CO. | 2004-01-29 | — | — | US | disclosed |
| US-6653326-B1 | For example, N-(2-hydroxy-3-(1-piperidinyl)propoxy)-3-pyridinecarboximidoyl chloride maleate; inducing gene expression of an eukaryotic cell under physiological stress; antiallergens; autoimmune diseases; cardiovascular disorders | BIOREX RESEARCH & DEVELOPMENT CO. (HU) | 2003-11-25 | — | — | US | disclosed |
| EP-0801649-B1 | HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULAR CHAPERON PRODUCTION AND THE PREPARATION THEREOF | BIOREX KUTATO FEJLESZTOE KFT (HU) | 2002-08-07 | — | — | EP | disclosed |
| EP-0832079-B1 | ANTI-ISCHAEMIC HYDROXYLAMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS | BIOREX KUTATO FEJLESZTOE KFT (HU) | 2002-03-27 | — | — | EP | disclosed |
| US-20010051630-A1 | Use of hydroxylamine derivatives, and method and preparations for increasing the tolerance of field crops against weather stresses | JEDNAKOVITS ANDREA (HU) | 2001-12-13 | — | — | US | disclosed |
| US-6002002-A | Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions | BIOREX RESEARCH & DEVELOPMENT CO. (HU) | 1999-12-14 | — | — | US | disclosed |
| EP-0832079-A1 | ANTI-ISCHAEMIC HYDROXYLAMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS | BIOREX KUTATO ES FEJLESZTÖ RT. (HU) | 1998-04-01 | — | — | EP | disclosed |
| WO-1997000251-A1 | ANTI-ISCHAEMIC HYDROXYLAMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS | BIOREX KUTATO ES FEJLESZTO RT. (HU) | 1997-01-03 | — | — | WO | disclosed |
| US-4897412-A | Imidazolines useful in lowering intraocular pressure | LABORATORIES ALCON S.A. (FR) | 1990-01-30 | — | — | US | disclosed |
| US-4801617-A | Iminoimidazolidines useful in lowering intraocular pressure | LABORATOIRES ALCON, S.A., 68240 KAYERSBERG, FRANCE, A CORP. OF FRANCE | 1989-01-31 | — | — | US | disclosed |
| WO-1988007995-A2 | COMPOUNDS POSSESSING BETA-ANTAGONISTIC AND ALPHA-ANTAGONISTIC PROERTIES, SUITABLE FOR LOWERING THE INTRAORBITAL PRESSURE, PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS, UTILIZATION THEREOF | LABORATOIRES ALCON S.A. (FR) | 1988-10-20 | — | — | WO | disclosed |
| US-4235899-A | ANTIPROTOZOA AGENTS ESPECIALLY AGAINST TRICHOMONAS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-11-25 | — | — | US | disclosed |