Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 10/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27240830 | 0.87 | BTK (0.58) | JAK2SYKFLT3BTKJAK3 | |
| SCHEMBL27240981 | 0.86 | SYK (0.56) | JAK2CDK2CCNA2SYKCCNA1 | |
| SCHEMBL29113540 | 0.86 | FLT3 (0.58) | JAK2CDK2FLT3CDK6JAK3 | |
| SCHEMBL29113555 | 0.85 | JAK2 (0.52) | JAK2CDK2CCNA2SYKCCNA1 | |
| SCHEMBL26980139 | 0.83 | JAK2 (0.51) | JAK2CDK2CCNA2SYKCCNA1 | |
| SCHEMBL29113558 | 0.82 | PTK2 (0.45) | — | |
| SCHEMBL30671851 | 0.79 | JAK2 (0.49) | JAK2CDK2SYKSTAT6KCNH2 | |
| SCHEMBL29113559 | 0.79 | JAK2 (0.49) | JAK2CDK2SYKSTAT6KCNH2 | |
| SCHEMBL29929747 | 0.78 | BTK (0.58) | JAK2FLT3BTKJAK3JAK1 | |
| SCHEMBL26980176 | 0.78 | BTK (0.58) | JAK2FLT3BTKJAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136184-A | Aminopyrimidine compounds and methods of use thereof | 泰拉生物科学公司 | 2023-11-28 | — | — | CN | disclosed |