Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.63 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KRAS | P01116 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.58 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8169633 | 0.85 | ABCG2 (0.86) | ABCG2CXCL12ATMALDH1A1KRAS | |
| SCHEMBL3733263 | 0.85 | ABCG2 (0.86) | ABCG2CXCL12ATMALDH1A1KRAS | |
| SCHEMBL4467303 | 0.83 | ABCG2 (0.53) | ABCG2CXCL12TNFRSF1AMEN1KMT2A | |
| SCHEMBL4467307 | 0.83 | ABCG2 (0.53) | ABCG2CXCL12TNFRSF1AMEN1KMT2A | |
| SCHEMBL3733260 | 0.80 | ABCG2 (0.86) | ABCG2CXCL12ATMALDH1A1KRAS | |
| SCHEMBL3738109 | 0.80 | CYP1A1 (0.67) | ABCG2CXCL12ATMCYP1A1CYP1B1 | |
| SCHEMBL8160826 | 0.80 | CYP1A1 (0.67) | ABCG2CXCL12ATMCYP1A1CYP1B1 | |
| SCHEMBL3735097 | 0.80 | ABCG2 (0.79) | ABCG2CXCL12ATMCYP1A1CYP1B1 | |
| SCHEMBL8175111 | 0.80 | ABCG2 (0.79) | ABCG2CXCL12ATMCYP1A1CYP1B1 | |
| SCHEMBL18551799 | 0.78 | ABCG2 (0.70) | ABCG2CXCL12ATMCYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4531824-A1 | CHALCONE DERIVATIVES, MODULATOR OF FIBROBLASTS, FOR USE IN THE TREATMENT OF STROMA-RICH TUMORS | Universiteit Gent (BE) | 2025-04-09 | — | — | EP | disclosed |
| CN-119451668-A | Chalcone derivatives and modulators of fibroblasts for the treatment of stromal rich tumors | 根特大学 | 2025-02-14 | — | — | CN | disclosed |
| WO-2023232866-A1 | CHALCONE DERIVATIVES, MODULATOR OF FIBROBLASTS, FOR USE IN THE TREATMENT OF STROMA-RICH TUMORS | UNIVERSITEIT GENT (BE) | 2023-12-07 | — | — | WO | disclosed |