SCHEMBL30677353

SCHEMBL30677353

Cc1cccc(C=NNc2nc(N3CCOCC3)nc3c(Br)cccc23)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.61
KDM4E B2RXH2 5/20 0.61
LMNA P02545 4/20 0.61
HPGD P15428 1/20 0.61
PIKFYVE Q9Y2I7 9/20 0.51
ATM Q13315 1/20 0.48
ALDH1A1 P00352 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
MEN1 O00255 1/20 0.46
NPC1 O15118 1/20 0.46
MAPK1 P28482 1/20 0.46
RAB9A P51151 1/20 0.46
KMT2A Q03164 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
FES P07332 1/20 0.45
FER P16591 1/20 0.45
TYK2 P29597 1/20 0.45
FRK P42685 1/20 0.45
SYK P43405 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31576443 1.00 MAPT (0.61) MAPTKDM4ELMNAHPGDPIKFYVE
SCHEMBL30676908 0.86 KDM4E (0.58) MAPTKDM4ELMNAHPGDPIKFYVE
SCHEMBL30677447 0.86 KDM4E (0.60) MAPTKDM4ELMNAHPGDPIKFYVE
SCHEMBL427088 0.85 KDM4E (0.64) MAPTKDM4ELMNAHPGDPIKFYVE
SCHEMBL427089 0.85 KDM4E (0.64) MAPTKDM4ELMNAHPGDPIKFYVE
SCHEMBL30676650 0.85 KDM4E (0.57) MAPTKDM4ELMNAHPGDPIKFYVE
SCHEMBL30677453 0.84 MAPT (0.58) MAPTKDM4ELMNAHPGDPIKFYVE
SCHEMBL31576457 0.84 MAPT (0.58) MAPTKDM4ELMNAHPGDPIKFYVE
SCHEMBL31576401 0.84 KDM4E (0.60) MAPTKDM4ELMNAHPGDPIKFYVE
SCHEMBL30677443 0.84 KDM4E (0.60) MAPTKDM4ELMNAHPGDPIKFYVE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024014885-A1 NOVEL BICYCLIC HETEROARYL COMPOUND AND USE THEREOF 일동제약(주) 2024-01-18 WO disclosed