Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Epinastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 13/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.97 |
| ▸ | HTR1A | P08908 | 3/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.97 |
| ▸ | DRD1 | P21728 | 2/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.97 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.97 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.97 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.97 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.97 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.97 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Epinastine SCHEMBL122749 | 1.00 | ADRA1A (0.97) | ADRA1AADRA2AHTR1AOPRM1DRD1 | |
| Epinastine SCHEMBL122751 | 1.00 | ADRA1A (0.97) | ADRA1AADRA2AHTR1AOPRM1DRD1 | |
| Epinastine SCHEMBL357588 | 0.98 | ADRA1A (1.00) | ADRA1AADRA2AHTR1AOPRM1DRD1 | |
| Epinastine SCHEMBL29945140 | 0.98 | ADRA1A (1.00) | ADRA1AADRA2AHTR1AOPRM1DRD1 | |
| Epinastine SCHEMBL18794 | 0.98 | ADRA1A (1.00) | ADRA1AADRA2AHTR1AOPRM1DRD1 | |
| Epinastine SCHEMBL4292213 | 0.97 | ADRA1A (0.97) | ADRA1AADRA2AHTR1AOPRM1DRD1 | |
| Epinastine SCHEMBL3989750 | 0.97 | ADRA1A (0.97) | ADRA1AADRA2AHTR1AOPRM1DRD1 | |
| Epinastine SCHEMBL3989748 | 0.97 | ADRA1A (0.97) | ADRA1AADRA2AHTR1AOPRM1DRD1 | |
| Epinastine SCHEMBL122750 | 0.96 | ADRA1A (0.94) | ADRA1AADRA2AHTR1AOPRM1DRD1 | |
| Epinastine SCHEMBL16093961 | 0.88 | ADRA1A (0.81) | ADRA1AADRA2AHTR1AOPRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115902067-B | Method for measuring content of corn starch in epinastine hydrochloride | 吉斯凯(苏州)制药有限公司 | 2023-09-26 | — | — | CN | disclosed |