Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.58 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.54 |
| ▸ | STAT3 | P40763 | 4/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | IL1B | P01584 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.52 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25894864 | 0.88 | CRBN (0.62) | CRBNDDB1HDAC1HDAC2STAT3 | |
| SCHEMBL23540271 | 0.87 | CRBN (0.69) | CRBNDDB1STAT3CA2 | |
| SCHEMBL23539211 | 0.87 | CRBN (0.65) | CRBNDDB1HDAC1HDAC2STAT3 | |
| SCHEMBL25878607 | 0.86 | CRBN (0.60) | CRBNDDB1HDAC1HDAC2STAT3 | |
| SCHEMBL23672358 | 0.85 | CRBN (0.58) | CRBNDDB1HDAC1HDAC2STAT3 | |
| SCHEMBL22835222 | 0.84 | CRBN (0.62) | CRBNDDB1HDAC1HDAC2STAT3 | |
| SCHEMBL25731148 | 0.84 | CRBN (0.56) | CRBNDDB1HDAC1HDAC2STAT3 | |
| SCHEMBL25733191 | 0.83 | CRBN (0.60) | CRBNDDB1HDAC1HDAC2STAT3 | |
| SCHEMBL23540331 | 0.83 | CRBN (0.67) | CRBNDDB1HDAC1HDAC2STAT3 | |
| SCHEMBL23672426 | 0.82 | CRBN (0.59) | CRBNDDB1HDAC1HDAC2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157298-A | Dual-function chimeric heterocyclic compound of interleukin-1 receptor related kinase 4, preparation method, medicinal composition and application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2023-12-01 | — | — | CN | disclosed |