Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3073344 | 0.84 | ERN1 (0.40) | ERN1KDM4EHTTGRM4FGFR4 | |
| SCHEMBL3068291 | 0.83 | KDM4E (0.44) | KDM4EHTTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3066971 | 0.83 | KDM4E (0.44) | KDM4EHTTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3069763 | 0.82 | ERN1 (0.46) | ERN1KDM4EHTTGRM4GRM5 | |
| SCHEMBL3070501 | 0.80 | KDM4E (0.42) | KDM4EHTTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3066951 | 0.79 | KDM4E (0.37) | KDM4EHTTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3052119 | 0.78 | ERN1 (0.37) | ERN1KDM4EHTTALDH1A1GAA | |
| SCHEMBL3057167 | 0.77 | KDM4E (0.41) | KDM4EHTTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3069860 | 0.77 | HTT (0.44) | KDM4EHTTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3062681 | 0.76 | KDM4E (0.42) | KDM4EHTTALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261719-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261719-A1 | CHEMICAL COMPOUNDS | NCOA3, NR4A3, NR0B2 | ERN1 1745/4885KDM4E 4486/4885HTT 2271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.