SCHEMBL30680829

SCHEMBL30680829

COc1c(N2CC3(CCNCC3)C2)cccc1S(=O)(=O)Nc1noc2cc(Cn3cccn3)cc(OC)c12

nearest known ligand 0.64

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KAT7 O95251 20/20 0.64
▸ KAT6A Q92794 20/20 0.64
▸ KAT6B Q8WYB5 13/20 0.63
▸ KAT5 Q92993 13/20 0.63
▸ KAT8 Q9H7Z6 13/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26969664 1.00 KAT7 (0.64) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26969649 0.91 KAT7 (0.69) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680841 0.91 KAT7 (0.69) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680851 0.88 KAT6A (0.69) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26969659 0.88 KAT6A (0.69) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26969632 0.86 KAT7 (0.69) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680845 0.86 KAT7 (0.69) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL31553513 0.84 KAT6A (0.51) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL31553510 0.84 KAT6A (0.51) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL29017507 0.84 KAT7 (0.81) KAT7KAT6AKAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4539937-A1 KAT6 TARGETING COMPOUNDS WITH UBIQUITIN LIGASE BINDING MOIETY Prelude Therapeutics Incorporated (US) 2025-04-23 — — EP disclosed
WO-2023245150-A9 KAT6 TARGETING COMPOUNDS WITH UBIQUITIN LIGASE BINDING MOIETY PRELUDE THERAPEUTICS INCORPORATED (US) 2025-01-16 — — WO disclosed
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