SCHEMBL30680846

SCHEMBL30680846

COc1cc(Cn2cccn2)cc2onc(NS(=O)(=O)c3cccc(Br)c3)c12

nearest known ligand 0.83

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KAT7 O95251 20/20 0.83
▸ KAT6A Q92794 20/20 0.83
▸ KAT6B Q8WYB5 9/20 0.82
▸ KAT5 Q92993 9/20 0.82
▸ KAT8 Q9H7Z6 9/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26969628 1.00 KAT7 (0.83) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680819 1.00 KAT7 (0.83) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22817349 0.91 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22817406 0.90 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL24866152 0.88 KAT6A (0.83) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22802508 0.88 KAT7 (0.83) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680835 0.88 KAT7 (0.83) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL31472950 0.88 KAT6A (0.83) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22817448 0.88 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30636992 0.88 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4539937-A1 KAT6 TARGETING COMPOUNDS WITH UBIQUITIN LIGASE BINDING MOIETY Prelude Therapeutics Incorporated (US) 2025-04-23 — — EP disclosed
CN-119836416-A KAT6 targeting compounds with ubiquitin ligase binding moiety 普莱鲁德疗法有限公司 2025-04-15 — — CN disclosed
WO-2023245150-A9 KAT6 TARGETING COMPOUNDS WITH UBIQUITIN LIGASE BINDING MOIETY PRELUDE THERAPEUTICS INCORPORATED (US) 2025-01-16 — — WO disclosed
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