SCHEMBL30684286

SCHEMBL30684286

C[Si](C)(C)CCOCn1ccc2ccc(Cl)c(Br)c21

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 5/20 0.39
PDE10A Q9Y233 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26913294 1.00 DGAT1 (0.39) DGAT1PDE10A
SCHEMBL31358007 0.84 DGAT1 (0.41) DGAT1PDE10A
SCHEMBL27657190 0.84 DGAT1 (0.37) DGAT1PDE10A
SCHEMBL26912896 0.81 DGAT1 (0.33) DGAT1
SCHEMBL6030125 0.78 DGAT1 (0.40) DGAT1PDE10A
SCHEMBL29079932 0.78 DGAT1 (0.38) DGAT1
SCHEMBL28601695 0.77 DGAT1 (0.41) DGAT1
SCHEMBL17200345 0.77 DGAT1 (0.37) DGAT1PDE10A
SCHEMBL14738392 0.77 DGAT1 (0.42) DGAT1PDE10A
SCHEMBL16192744 0.76 DGAT1 (0.37) DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023235809-A1 CGAS INHIBITORS ELI LILLY AND COMPANY (US) 2023-12-07 WO disclosed