Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14567836 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL25837923 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL2062103 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL26870536 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL20214723 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| Hydrochloric Acid SCHEMBL26618203 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL31509441 | 0.81 | NPC1 (0.44) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL9080448 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL16144687 | 0.77 | MAPT (0.51) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL6652311 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4547662-A1 | IMIDAZO[4,5-B]PYRIDINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS SIK MODULATORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS | F. Hoffmann-La Roche AG (CH) | 2025-05-07 | — | — | EP | disclosed |
| US-20250127780-A1 | IMIDAZO[4,5-B]PYRIDINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS SIK MODULATORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS | HOFFMANN-LA ROCHE INC. (US) | 2025-04-24 | — | — | US | disclosed |
| WO-2024003208-A1 | IMIDAZO[4,5-B]PYRIDINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS SIK MODULATORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250127780-A1 | IMIDAZO[4,5-B]PYRIDINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS SIK MODULATORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS | SIK1, SIK2, SIK3 | SMN1; SMN2 4149/4885ALDH1A1 830/4885MAPT 4496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.