Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | PDE1A | P54750 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9070573 | 0.98 | ALDH1A1 (0.43) | ALDH1A1POLBKMT2ATLR8PDE4A | |
| Bromide SCHEMBL28118817 | 0.89 | ALDH1A1 (0.56) | ALDH1A1POLBKMT2ATLR8ADORA2A | |
| SCHEMBL29391 | 0.87 | ALDH1A1 (0.58) | ALDH1A1POLBKMT2ATLR8ADORA2A | |
| SCHEMBL28155209 | 0.86 | ALDH1A1 (0.56) | ALDH1A1POLBKMT2ATLR8ADORA2A | |
| SCHEMBL7203009 | 0.86 | TLR8 (0.57) | ALDH1A1POLBKMT2ATLR8 | |
| Bromide SCHEMBL30948884 | 0.85 | MAPT (0.37) | ALDH1A1POLBKMT2ATLR8 | |
| SCHEMBL28278332 | 0.84 | TLR8 (0.56) | ALDH1A1POLBKMT2ATLR8 | |
| SCHEMBL3419618 | 0.84 | TLR8 (0.56) | ALDH1A1POLBKMT2ATLR8 | |
| SCHEMBL6886638 | 0.82 | — | — | |
| SCHEMBL28877651 | 0.82 | ALDH1A1 (0.51) | ALDH1A1POLBKMT2ATLR8ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117143292-A | Preparation method and application of modified gelatin-poly (acrylic acid-ionic liquid) hydrogel with adjustable adhesiveness | 大连工业大学 | 2023-12-01 | — | — | CN | claimed |
| CN-117143292-A | Preparation method and application of modified gelatin-poly (acrylic acid-ionic liquid) hydrogel with adjustable adhesiveness | 大连工业大学 | 2023-12-01 | — | — | CN | disclosed |
| CN-117143292-A | Preparation method and application of modified gelatin-poly (acrylic acid-ionic liquid) hydrogel with adjustable adhesiveness | 大连工业大学 | 2023-12-01 | — | — | CN | disclosed |