Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | GALK1 | P51570 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzyl Alcohol SCHEMBL2963501 | 0.84 | TSHR (0.67) | TSHRALDH1A1LMNA | |
| SCHEMBL123838 | 0.83 | TSHR (0.61) | ENPP2TSHRPRSS1PRSS2PRSS3 | |
| SCHEMBL30036663 | 0.81 | TSHR (0.67) | TSHRTRPV1ALDH1A1LMNA | |
| SCHEMBL94846 | 0.81 | TSHR (0.67) | TSHRTRPV1ALDH1A1LMNA | |
| SCHEMBL3069413 | 0.81 | TMEM97 (0.46) | ENPP2TSHRPRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL14334287 | 0.80 | ENPP2 (0.58) | ENPP2TSHRPRSS1PRSS2PRSS3 | |
| SCHEMBL10490768 | 0.79 | TSHR (0.65) | TSHRTRPV1ALDH1A1LMNA | |
| Methane SCHEMBL27717284 | 0.79 | TSHR (0.65) | TSHRTRPV1ALDH1A1LMNA | |
| SCHEMBL17347330 | 0.78 | TSHR (0.44) | ENPP2TSHRPRSS1PRSS2PRSS3 | |
| Iodide SCHEMBL4931657 | 0.78 | TSHR (0.62) | TSHRTRPV1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |