Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10286040 | 1.00 | HDAC1 (0.42) | HDAC1HDAC8HDAC6CHRM4DRD2 | |
| SCHEMBL14885005 | 1.00 | HDAC1 (0.42) | HDAC1HDAC8HDAC6CHRM4DRD2 | |
| SCHEMBL3955281 | 0.92 | CHRM4 (0.40) | HDAC1HDAC8HDAC6CHRM4DRD2 | |
| SCHEMBL10286027 | 0.84 | CHRM4 (0.39) | CHRM4DRD2HTR7HTR2AHTR2C | |
| SCHEMBL10286160 | 0.83 | CHRM4 (0.39) | CHRM4DRD2HTR7HTR2AHTR2C | |
| SCHEMBL30484353 | 0.83 | CHRM4 (0.39) | CHRM4DRD2HTR7HTR2AHTR2C | |
| SCHEMBL10286793 | 0.81 | CHRM4 (0.38) | CHRM4DRD2HTR7CYP19A1ALDH1A1 | |
| SCHEMBL14885003 | 0.79 | CHRM4 (0.41) | HDAC8HDAC6CHRM4DRD2HTR7 | |
| SCHEMBL10286028 | 0.79 | CHRM4 (0.41) | HDAC8HDAC6CHRM4DRD2HTR7 | |
| SCHEMBL4761653 | 0.78 | HDAC1 (0.40) | HDAC1HDAC8HDAC6HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4536664-A1 | DEGRADATION OF IRAK4 BY CONJUGATION OF IRAK4 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BeiGene, Ltd. (KY) | 2025-04-16 | — | — | EP | disclosed |
| CN-119403805-A | Degradation of IRAK4 by conjugation of IRAK4 inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2025-02-07 | — | — | CN | disclosed |
| WO-2023237049-A1 | DEGRADATION OF IRAK4 BY CONJUGATION OF IRAK4 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-12-14 | — | — | WO | disclosed |