SCHEMBL30697100

SCHEMBL30697100

Nc1cc(C=O)nc(C(F)(F)F)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
GRM4 Q14833 1/20 0.38
KDM4E B2RXH2 6/20 0.35
HSD17B10 Q99714 2/20 0.35
CA2 P00918 1/20 0.34
CHKA P35790 1/20 0.34
KMT2A Q03164 2/20 0.34
PTGS2 P35354 1/20 0.33
HPGD P15428 3/20 0.31
LMNA P02545 2/20 0.31
PKM P14618 2/20 0.31
ALPL P05186 2/20 0.31
ALPI P09923 2/20 0.31
CDK8 P49336 1/20 0.31
CDK19 Q9BWU1 1/20 0.31
GAA P10253 1/20 0.31
LOXL2 Q9Y4K0 1/20 0.31
MEN1 O00255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27076937 1.00 ALDH1A1 (0.41) ALDH1A1HSP90AA1HSP90AB1GRM4KDM4E
SCHEMBL27330869 0.81 GRM4 (0.57) ALDH1A1HSP90AA1HSP90AB1GRM4KDM4E
SCHEMBL8788157 0.79 HSP90AA1 (0.52) ALDH1A1HSP90AA1HSP90AB1GRM4KDM4E
SCHEMBL29155479 0.79 CCR1 (0.39) ALDH1A1
SCHEMBL28664997 0.77 NT5E (0.38) ALDH1A1HSP90AA1HSP90AB1GRM4KDM4E
SCHEMBL23536720 0.73 ALDH1A1 (0.38) ALDH1A1HSP90AA1HSP90AB1GRM4KDM4E
SCHEMBL16516311 0.73 ALPI (0.37) ALDH1A1HSP90AA1HSP90AB1KDM4EHSD17B10
SCHEMBL23608618 0.73 HSP90AA1 (0.47) ALDH1A1HSP90AA1HSP90AB1GRM4KDM4E
SCHEMBL29883397 0.71 HSP90AA1 (0.45) ALDH1A1HSP90AA1HSP90AB1GRM4KDM4E
SCHEMBL23580669 0.71 HSP90AA1 (0.45) ALDH1A1HSP90AA1HSP90AB1GRM4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117098764-A Tetrahydrothienopyridine derivatives as DDR inhibitors 奇斯药制品公司 2023-11-21 CN disclosed
CN-117062812-A Indoline derivatives as DDR inhibitors 奇斯药制品公司 2023-11-14 CN disclosed