Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | PRKCH | P24723 | 5/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 6/20 | 0.34 |
| ▸ | IL1B | P01584 | 3/20 | 0.34 |
| ▸ | PRKCB | P05771 | 2/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.32 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | LATS1 | O95835 | 1/20 | 0.30 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24379593 | 0.93 | NLRP3 (0.39) | NLRP3PRKCHPRKCQPRKCEPRKCD | |
| SCHEMBL24379643 | 0.89 | TTK (0.36) | NLRP3PRKCHPRKCQPRKCEPRKCD | |
| SCHEMBL29875211 | 0.89 | NLRP3 (0.36) | NLRP3PRKCHPRKCQPRKCEPRKCD | |
| SCHEMBL30571301 | 0.87 | KDR (0.38) | NLRP3PRKCHPRKCQPRKCEPRKCD | |
| SCHEMBL29875272 | 0.86 | PRKCH (0.33) | NLRP3PRKCHPRKCQPRKCEPRKCD | |
| SCHEMBL24379633 | 0.86 | NLRP3 (0.40) | NLRP3PRKCHPRKCQPRKCEPRKCD | |
| SCHEMBL24379625 | 0.82 | NLRP3 (0.38) | NLRP3PRKCHPRKCQPRKCEPRKCD | |
| SCHEMBL32660756 | 0.82 | KDR (0.37) | NLRP3PRKCHPRKCQPRKCEPRKCD | |
| SCHEMBL24379571 | 0.82 | KDR (0.37) | NLRP3PRKCHPRKCQPRKCEPRKCD | |
| SCHEMBL24379641 | 0.81 | KMT2A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117510495-A | Pyridazine compounds for inhibiting NLRP3 | 万特斯治疗美国公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-117500792-A | Pyridazine compounds for inhibiting NLRP3 | 万特斯治疗美国公司 | 2024-02-02 | — | — | CN | disclosed |