Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GPR88 | Q9GZN0 | 11/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12112442 | 0.91 | TSHR (0.56) | GAATSHRMAPTALDH1A1LMNA | |
| SCHEMBL9252696 | 0.88 | MAPT (0.62) | GAATSHRMAPTALDH1A1LMNA | |
| SCHEMBL10804894 | 0.87 | TSHR (0.48) | GAATSHRGPR88 | |
| SCHEMBL10804900 | 0.87 | TSHR (0.48) | GAATSHRGPR88 | |
| SCHEMBL8081903 | 0.84 | MAPK1 (0.59) | TSHRGPR88 | |
| SCHEMBL11349081 | 0.84 | MAPT (0.57) | GAATSHRMAPTALDH1A1LMNA | |
| SCHEMBL20765902 | 0.82 | MAPT (0.68) | GAATSHRMAPTALDH1A1LMNA | |
| SCHEMBL9487537 | 0.82 | TSHR (0.50) | GAATSHRMAPTGPR88KMT2A | |
| SCHEMBL9487539 | 0.82 | TSHR (0.50) | GAATSHRMAPTGPR88KMT2A | |
| SCHEMBL27243771 | 0.81 | MAPT (0.66) | GAATSHRMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543857-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | ACADIA Pharmaceuticals Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| CN-119546577-A | Modulators of G protein-coupled receptor 88 | 阿卡蒂亚药品公司 | 2025-02-28 | — | — | CN | disclosed |
| WO-2023250060-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | ACADIA PHARMACEUTICALS INC. (US) | 2023-12-28 | — | — | WO | disclosed |