Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 7/20 | 0.50 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737362 | 1.00 | ITK (0.50) | ITKKIF11MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL13115653 | 0.85 | ABL1 (0.48) | ITKMAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL30310978 | 0.85 | ITK (0.45) | ITKKIF11MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL14493350 | 0.84 | MAP2K4 (0.53) | ITKMAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL29937023 | 0.83 | ITK (0.40) | ITKMAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL31552439 | 0.79 | ITK (0.53) | ITKKIF11MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL2826429 | 0.79 | NOS1 (0.39) | ITKMAP2K4 | |
| SCHEMBL12247 | 0.79 | ITK (0.53) | ITKKIF11MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL497271 | 0.78 | PDPK1 (0.60) | ITK | |
| SCHEMBL1330584 | 0.76 | PDPK1 (0.63) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006379-A1 | METHODS AND COMPOUNDS FOR INHIBITING MKK7 ENZYMES | AXONIS THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |