Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 14/20 | 0.36 |
| ▸ | EGFR | P00533 | 8/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30699944 | 0.88 | CHRM4 (0.35) | HRH3BTKRXRB | |
| SCHEMBL30700586 | 0.88 | CHRM4 (0.35) | HRH3BTKRXRB | |
| SCHEMBL30700483 | 0.86 | HRH3 (0.43) | HRH3RXRB | |
| SCHEMBL30700060 | 0.86 | HRH3 (0.43) | HRH3RXRB | |
| SCHEMBL30700439 | 0.80 | SCN9A (0.38) | HRH3KCNH2 | |
| SCHEMBL30699964 | 0.77 | SCN9A (0.40) | HRH3KCNH2 | |
| SCHEMBL27291672 | 0.77 | SCN9A (0.40) | HRH3KCNH2 | |
| SCHEMBL30700532 | 0.75 | PARP10 (0.44) | HRH3KCNH2BTKTRPC6 | |
| SCHEMBL30700128 | 0.75 | PARP10 (0.44) | HRH3KCNH2BTKTRPC6 | |
| SCHEMBL27291568 | 0.75 | PARP10 (0.44) | HRH3KCNH2BTKTRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |