Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 7/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30553263 | 0.95 | MGLL (0.38) | MGLLCYP11B1CYP11B2OPRL1 | |
| SCHEMBL25327858 | 0.95 | MGLL (0.38) | MGLLCYP11B1CYP11B2OPRL1 | |
| SCHEMBL30553170 | 0.85 | MGLL (0.39) | MGLLCYP11B1CYP11B2SPR | |
| SCHEMBL25324465 | 0.85 | MGLL (0.39) | MGLLCYP11B1CYP11B2SPR | |
| SCHEMBL30699890 | 0.82 | MGLL (0.41) | MGLL | |
| SCHEMBL25326308 | 0.81 | MGLL (0.39) | MGLLOPRL1 | |
| SCHEMBL30553281 | 0.81 | MGLL (0.39) | MGLLOPRL1 | |
| SCHEMBL30700294 | 0.80 | MGLL (0.40) | MGLLCYP11B1CYP11B2 | |
| SCHEMBL31549750 | 0.79 | BACE1 (0.36) | MGLLCYP11B1CYP11B2SPROPRL1 | |
| SCHEMBL30699919 | 0.78 | MGLL (0.40) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |