Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | YAP1 | P46937 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3257929 | 0.94 | GPR119 (0.55) | GPR119SYKYAP1HTTP2RX7 | |
| SCHEMBL20660016 | 0.94 | GPR119 (0.55) | GPR119SYKYAP1HTTP2RX7 | |
| SCHEMBL903626 | 0.94 | GPR119 (0.55) | GPR119SYKYAP1HTTP2RX7 | |
| SCHEMBL15898105 | 0.92 | SYK (0.49) | GPR119SYKYAP1HTTP2RX7 | |
| SCHEMBL21062628 | 0.87 | GPR119 (0.56) | GPR119SYKYAP1P2RX7L3MBTL1 | |
| SCHEMBL22552461 | 0.87 | GPR119 (0.56) | GPR119SYKYAP1P2RX7L3MBTL1 | |
| SCHEMBL22552460 | 0.87 | GPR119 (0.56) | GPR119SYKYAP1P2RX7L3MBTL1 | |
| SCHEMBL30700603 | 0.86 | GPR119 (0.53) | GPR119SYKYAP1HTTP2RX7 | |
| SCHEMBL29290631 | 0.86 | GPR119 (0.53) | GPR119SYKYAP1HTTP2RX7 | |
| SCHEMBL29584128 | 0.86 | GPR119 (0.53) | GPR119SYKYAP1HTTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |