SCHEMBL30701035

SCHEMBL30701035

COc1nc2ccc(Br)cc2cc1Cc1cccc(F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 6/20 0.42
CYP3A4 P08684 4/20 0.42
PRNP P04156 2/20 0.41
MAOB P27338 2/20 0.39
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
MAPT P10636 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
CACNA1C Q13936 1/20 0.37
MGAM O43451 2/20 0.37
GAA P10253 2/20 0.37
SI P14410 2/20 0.37
MGAM2 Q2M2H8 2/20 0.37
FPR1 P21462 1/20 0.37
FPR2 P25090 1/20 0.37
MPO P05164 1/20 0.36
HTR2A P28223 1/20 0.36
SLC6A4 P31645 1/20 0.36
HTR6 P50406 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19354154 1.00 KCNH2 (0.42) KCNH2CYP3A4PRNPMAOBCYP1A2
SCHEMBL28446574 0.90 ADORA2A (0.41) KCNH2MAOBCACNA1CHTR2A
SCHEMBL19331225 0.86 KCNH2 (0.43) KCNH2CYP3A4MAOBMAPTCACNA1C
SCHEMBL296886 0.86 KCNH2 (0.42) KCNH2PRNPCACNA1CHTR2A
SCHEMBL15352415 0.85 PRNP (0.41) KCNH2PRNPCACNA1CFPR1FPR2
SCHEMBL19330301 0.82 CYP17A1 (0.39) KCNH2MAOBGAA
SCHEMBL19354042 0.82 KCNH2 (0.39) KCNH2CYP3A4CACNA1CMPOHTR2A
SCHEMBL30701237 0.82 KCNH2 (0.39) KCNH2CYP3A4CACNA1CMPOHTR2A
SCHEMBL13440257 0.81 PLA2G2A (0.44) CYP3A4CYP1A2MAPTCYP2C9CYP2C19
SCHEMBL12277874 0.80 KCNH2 (0.37) KCNH2CYP3A4MAOBCYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109069514-B Antibacterial compound and application thereof 结核病药物开发全球联盟公司 2023-12-29 CN disclosed