Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPPL1 | O15357 | 3/20 | 0.71 |
| ▸ | MET | P08581 | 13/20 | 0.70 |
| ▸ | JAK2 | O60674 | 5/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.50 |
| ▸ | MAP4K3 | Q8IVH8 | 3/20 | 0.50 |
| ▸ | JAK3 | P52333 | 3/20 | 0.50 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | FES | P07332 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.50 |
| ▸ | LYN | P07948 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | ROS1 | P08922 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30701906 | 1.00 | INPPL1 (0.71) | INPPL1METJAK2ALKMAP4K3 | |
| SCHEMBL30701927 | 1.00 | INPPL1 (0.71) | INPPL1METJAK2ALKMAP4K3 | |
| SCHEMBL30701914 | 0.85 | INPPL1 (0.69) | INPPL1METJAK2ALKMAP4K3 | |
| SCHEMBL16324786 | 0.83 | INPPL1 (1.00) | INPPL1METJAK2ALKMAP4K3 | |
| SCHEMBL16324788 | 0.83 | INPPL1 (1.00) | INPPL1METJAK2ALKMAP4K3 | |
| SCHEMBL30701911 | 0.82 | MET (0.60) | INPPL1METFGFR3KDRFLT3 | |
| SCHEMBL30701920 | 0.82 | MET (0.60) | INPPL1METFGFR3KDRFLT3 | |
| Hydrochloric Acid SCHEMBL30701910 | 0.76 | INPPL1 (0.98) | INPPL1METJAK2ALKMAP4K3 | |
| SCHEMBL15942449 | 0.76 | MAP4K3 (0.58) | INPPL1METMAP4K3IRAK1IRAK4 | |
| SCHEMBL30701905 | 0.74 | INPPL1 (0.75) | INPPL1METALKMAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554936-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | The Trustees of Indiana University (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015759-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2024-01-18 | — | — | WO | disclosed |