Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | F13A1 | P00488 | 2/20 | 0.32 |
| ▸ | TGM2 | P21980 | 2/20 | 0.32 |
| ▸ | TGM1 | P22735 | 2/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31068605 | 0.89 | USP2 (0.38) | NR1H2USP2SMN1; SMN2HPGDATM | |
| SCHEMBL22022990 | 0.85 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL3494732 | 0.85 | USP2 (0.43) | NR1H2USP2SMN1; SMN2HPGDATM | |
| SCHEMBL12802260 | 0.81 | USP2 (0.40) | NR1H2USP2SMN1; SMN2HPGDHTT | |
| SCHEMBL10150809 | 0.81 | USP2 (0.40) | NR1H2USP2SMN1; SMN2HPGDHTT | |
| SCHEMBL18588199 | 0.81 | NR1H2 (0.44) | NR1H2USP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL29217880 | 0.80 | USP2 (0.39) | NR1H2USP2SMN1; SMN2HPGDHTT | |
| SCHEMBL24936235 | 0.80 | NR1H2 (0.43) | NR1H2USP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL28972177 | 0.80 | USP2 (0.45) | NR1H2USP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL29347019 | 0.79 | USP2 (0.37) | NR1H2USP2SMN1; SMN2HPGDEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554939-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | Astrazeneca AB (SE) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024013209-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2024-01-18 | — | — | WO | disclosed |