Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30704219 | 1.00 | MEN1 (0.38) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL26932712 | 0.77 | GRM5 (0.31) | — | |
| SCHEMBL26932647 | 0.77 | GRM5 (0.31) | — | |
| SCHEMBL26947377 | 0.75 | — | — | |
| SCHEMBL30673572 | 0.74 | ALDH1A1 (0.51) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL29860671 | 0.74 | CA12 (0.44) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL5229354 | 0.74 | BACE1 (0.39) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL30673550 | 0.74 | ALDH1A1 (0.51) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL5225981 | 0.74 | BACE1 (0.39) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL6139928 | 0.74 | BACE1 (0.39) | MEN1KMT2AMAPTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025122619-A1 | KRAS G12C INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-06-12 | — | — | WO | disclosed |
| EP-4536668-A1 | PYRIDO[4,3-D]PYRIMIDINE DERIVATIVES AS KRAS INHIBITORS | Bristol-Myers Squibb Company (US) | 2025-04-16 | — | — | EP | disclosed |
| CN-119630676-A | Pyrido [4,3-D ] pyrimidine derivatives as KRAS inhibitors | 百时美施贵宝公司 | 2025-03-14 | — | — | CN | disclosed |
| US-20240067662-A1 | KRAS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2024-02-29 | — | — | US | disclosed |
| WO-2023240188-A1 | PYRIDO[4,3-D]PYRIMIDINE DERIVATIVES AS KRAS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067662-A1 | KRAS INHIBITORS | KRAS, NRAS, HRAS | MEN1 1373/4885KMT2A 1739/4885MAPT 3872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.