Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.37 |
| ▸ | CDK9 | P50750 | 8/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.36 |
| ▸ | CDK2 | P24941 | 7/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24240378 | 1.00 | EGFR (0.37) | EGFRCDK9CCNT1CCNE1CDK2 | |
| SCHEMBL29162975 | 0.94 | EGFR (0.38) | EGFRCDK9CCNT1CCNE1CDK2 | |
| SCHEMBL24240390 | 0.91 | EGFR (0.44) | EGFRCDK9CCNT1CCNE1CDK2 | |
| SCHEMBL24496892 | 0.87 | EGFR (0.39) | EGFRCDK9CCNT1CCNE1CDK2 | |
| SCHEMBL24240388 | 0.87 | EGFR (0.50) | EGFR | |
| SCHEMBL18606916 | 0.86 | FGFR3 (0.35) | EGFRCDK9CCNT1CCNE1CDK2 | |
| SCHEMBL30705259 | 0.84 | MKNK1 (0.45) | EGFRCDK9CCNT1CCNE1CDK2 | |
| SCHEMBL24240383 | 0.84 | MKNK1 (0.45) | EGFRCDK9CCNT1CCNE1CDK2 | |
| SCHEMBL24240376 | 0.84 | EGFR (0.38) | EGFRCDK9CCNT1CCNE1CDK2 | |
| SCHEMBL30460067 | 0.80 | EGFR (0.54) | EGFRJAK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111747950-B | Pyrimidine derivatives for the treatment of cancer | 深圳福沃药业有限公司 | 2024-01-23 | — | — | CN | disclosed |