Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 8/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24240383 | 1.00 | MKNK1 (0.45) | MKNK1MKNK2PTK2EGFRCDK9 | |
| SCHEMBL24240390 | 0.93 | EGFR (0.44) | MKNK1MKNK2EGFRCDK9CCNT1 | |
| SCHEMBL24240376 | 0.91 | EGFR (0.38) | MKNK1MKNK2EGFRCDK9CCNT1 | |
| SCHEMBL30705245 | 0.87 | CCNT1 (0.36) | MKNK1MKNK2EGFRCDK9CCNT1 | |
| SCHEMBL24240392 | 0.87 | CCNT1 (0.36) | MKNK1MKNK2EGFRCDK9CCNT1 | |
| SCHEMBL22509274 | 0.84 | EGFR (0.51) | EGFRBTKALK | |
| SCHEMBL30705253 | 0.84 | EGFR (0.37) | PTK2EGFRCDK9CCNT1CCNE1 | |
| SCHEMBL24240378 | 0.84 | EGFR (0.37) | PTK2EGFRCDK9CCNT1CCNE1 | |
| SCHEMBL24496892 | 0.83 | EGFR (0.39) | EGFRCDK9CCNT1CCNE1CDK2 | |
| SCHEMBL29162975 | 0.83 | EGFR (0.38) | PTK2EGFRCDK9CCNT1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111747950-B | Pyrimidine derivatives for the treatment of cancer | 深圳福沃药业有限公司 | 2024-01-23 | — | — | CN | disclosed |