Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16998686 | 1.00 | HTR2A (0.41) | HTR2ASLC6A4KCNH2ALDH1A1MAPT | |
| SCHEMBL30474183 | 0.82 | IDO1 (0.35) | HTR2ASLC6A4KCNH2ALDH1A1MAPT | |
| SCHEMBL16998685 | 0.82 | IDO1 (0.35) | HTR2ASLC6A4KCNH2ALDH1A1MAPT | |
| SCHEMBL8237259 | 0.79 | HTR2A (0.42) | HTR2ASLC6A4KCNH2ALDH1A1MAPT | |
| SCHEMBL16752294 | 0.79 | KMT2A (0.48) | HTR2ASLC6A4KCNH2ALDH1A1MAPT | |
| SCHEMBL10019194 | 0.78 | KCNH2 (0.39) | HTR2ASLC6A4KCNH2ALDH1A1MAPT | |
| SCHEMBL233314 | 0.78 | TAAR1 (0.41) | HTR2AALDH1A1MAPTPOLBTAAR1 | |
| SCHEMBL2735698 | 0.77 | HTR2A (0.41) | HTR2ASLC6A4KCNH2ALDH1A1MAPT | |
| SCHEMBL6111929 | 0.77 | PNMT (0.48) | HTR2ASLC6A4KCNH2ALDH1A1MAPT | |
| SCHEMBL320779 | 0.77 | HTR2A (0.41) | HTR2ASLC6A4KCNH2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540255-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244615-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |