Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30707514 | 0.76 | DGAT1 (0.31) | KLKB1DGAT1 | |
| SCHEMBL25239263 | 0.67 | DGAT1 (0.33) | DGAT1 | |
| SCHEMBL31074699 | 0.66 | EPHX2 (0.34) | KLKB1DGAT1 | |
| SCHEMBL29050026 | 0.66 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL28593694 | 0.66 | DGAT1 (0.35) | KLKB1DGAT1 | |
| SCHEMBL31219625 | 0.66 | DGAT1 (0.34) | DGAT1 | |
| SCHEMBL23448329 | 0.66 | NPC1 (0.33) | DGAT1 | |
| SCHEMBL30706688 | 0.65 | PTGER3 (0.32) | DGAT1 | |
| SCHEMBL30946880 | 0.65 | NPC1 (0.32) | DGAT1 | |
| SCHEMBL28547571 | 0.65 | DGAT1 (0.38) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540254-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| EP-4540255-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| CN-119677749-A | Azaquinazoline pan KRAS inhibitors | 米拉蒂治疗股份有限公司 | 2025-03-21 | — | — | CN | disclosed |
| WO-2023244604-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |
| WO-2023244615-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |