Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 3/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | PRKACA | P17612 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | CDK8 | P49336 | 2/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30684499 | 0.87 | MAP2K1 (0.54) | MAP2K1CDC7ROCK2PRKACACLK4 | |
| SCHEMBL27583281 | 0.80 | MAP2K1 (0.49) | MAP2K1CDC7ROCK2PRKACACLK4 | |
| SCHEMBL2511843 | 0.79 | SLC22A6 (0.58) | MAP2K1CDC7DYRK1AKMT2AKDM4E | |
| SCHEMBL10599504 | 0.79 | SLC22A6 (0.61) | KMT2AKDM4EMEN1RECQLMTNR1A | |
| SCHEMBL1558087 | 0.78 | MAP2K1 (0.55) | MAP2K1CDC7KMT2AMTNR1ACDK2 | |
| SCHEMBL6225557 | 0.76 | MAP2K1 (0.54) | MAP2K1CDC7PRKACACLK4CDK8 | |
| SCHEMBL28258881 | 0.75 | SLC22A6 (0.60) | KMT2AKDM4EMEN1RECQLMTNR1A | |
| SCHEMBL1558071 | 0.74 | MAP2K1 (0.51) | MAP2K1CDC7ROCK2PRKACACLK4 | |
| SCHEMBL29000165 | 0.74 | SLC22A6 (0.58) | KMT2AKDM4EMEN1RECQLMTNR1A | |
| SCHEMBL4558873 | 0.74 | SLC22A6 (0.58) | KMT2AKDM4EMEN1RECQLMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295746-A | HPK1 inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2023-12-26 | — | — | CN | disclosed |