SCHEMBL30717133

SCHEMBL30717133

C[Si]1(C)CCN(c2cc(NS(C)(=O)=O)ccc2C(=O)Nc2cccc(OC[C@@H](O)C(F)(F)F)n2)CC1

nearest known ligand 0.67

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30717115 1.00 KIF18A (0.67) KIF18A
SCHEMBL30717053 0.91 KIF18A (0.81) KIF18A
SCHEMBL30717111 0.91 KIF18A (0.81) KIF18A
SCHEMBL30717178 0.91 KIF18A (0.81) KIF18A
SCHEMBL30717118 0.90 KIF18A (0.66) KIF18A
SCHEMBL30717093 0.90 KIF18A (0.66) KIF18A
SCHEMBL30716999 0.85 KIF18A (0.63) KIF18A
SCHEMBL30717079 0.85 KIF18A (0.63) KIF18A
SCHEMBL30717128 0.84 KIF18A (0.64) KIF18A
SCHEMBL30717076 0.84 KIF18A (0.64) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4572855-A1 INHIBITORS OF KIF18A AND USES THEREOF Accent Therapeutics, Inc. (US) 2025-06-25 — — EP disclosed
WO-2024039829-A1 INHIBITORS OF KIF18A AND USES THEREOF ACCENT THERAPEUTICS, INC. (US) 2024-02-22 — — WO disclosed
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