SCHEMBL30717448

SCHEMBL30717448

O=C(CC1CCCC1)N1CCc2nc(N3CC4CCC(C3)N4)sc2C1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.45
ADORA1 P30542 1/20 0.45
GRM5 P41594 10/20 0.45
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
UCHL1 P09936 2/20 0.34
MAPK14 Q16539 1/20 0.34
SIGMAR1 Q99720 1/20 0.34
PARK7 Q99497 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HSD17B10 Q99714 1/20 0.34
OGA O60502 1/20 0.34
F10 P00742 1/20 0.33
CTSB P07858 1/20 0.33
CTSS P25774 1/20 0.33
CTSK P43235 1/20 0.33
NAMPT P43490 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30717361 0.97 ADORA2A (0.45) ADORA2AADORA1GRM5NPC1RAB9A
SCHEMBL31748855 0.85 ADORA2A (0.47) ADORA2AADORA1GRM5NPC1RAB9A
SCHEMBL30717539 0.81 GRM5 (0.46) ADORA2AADORA1GRM5NPC1RAB9A
SCHEMBL30717316 0.81 ADORA2A (0.42) ADORA2AADORA1GRM5NPC1RAB9A
SCHEMBL30717397 0.81 ADORA2A (0.42) ADORA2AADORA1GRM5NPC1RAB9A
SCHEMBL30717460 0.81 GRM5 (0.43) ADORA2AADORA1GRM5NPC1RAB9A
SCHEMBL30717447 0.81 GRM5 (0.43) ADORA2AADORA1GRM5NPC1RAB9A
SCHEMBL30717359 0.79 GRM5 (0.45) ADORA2AADORA1GRM5NPC1RAB9A
SCHEMBL30717425 0.79 GRM5 (0.43) ADORA2AADORA1GRM5NPC1RAB9A
SCHEMBL30717671 0.79 GRM5 (0.52) ADORA2AADORA1GRM5NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4572762-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS Mironid Limited (GB) 2025-06-25 EP claimed
WO-2024038128-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS MIRONID LIMITED (GB) 2024-02-22 WO claimed
EP-4572762-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS Mironid Limited (GB) 2025-06-25 EP disclosed
WO-2024038128-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS MIRONID LIMITED (GB) 2024-02-22 WO disclosed