Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.53 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.53 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23496971 | 1.00 | HDAC3 (0.53) | HDAC3IDO1EP300KAT2BKAT8 | |
| SCHEMBL30719597 | 1.00 | HDAC3 (0.53) | HDAC3IDO1EP300KAT2BKAT8 | |
| SCHEMBL30719600 | 0.86 | TLR8 (0.57) | IDO1TLR8HSD17B1HSD17B2ESR2 | |
| SCHEMBL23496970 | 0.86 | TLR8 (0.57) | IDO1TLR8HSD17B1HSD17B2ESR2 | |
| SCHEMBL13678995 | 0.82 | TLR8 (0.70) | TLR8HSD17B1HSD17B2ESR2CYP3A4 | |
| SCHEMBL30719615 | 0.78 | TLR8 (0.74) | TLR8HSD17B1HSD17B2ESR2CYP3A4 | |
| SCHEMBL22078735 | 0.78 | TLR8 (0.74) | TLR8HSD17B1HSD17B2ESR2CYP3A4 | |
| SCHEMBL23496933 | 0.78 | TLR8 (0.52) | IDO1EP300KAT8TLR8HSD17B1 | |
| SCHEMBL30719599 | 0.78 | TLR8 (0.52) | IDO1EP300KAT8TLR8HSD17B1 | |
| SCHEMBL14417224 | 0.77 | IDO1 (0.48) | HDAC3IDO1EP300KAT2BKAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586191-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-111542515-B | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2023-12-05 | — | — | CN | disclosed |