Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.57 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.54 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23496970 | 1.00 | TLR8 (0.57) | TLR8HSD17B1HSD17B2IDO1ESR2 | |
| SCHEMBL14417224 | 0.91 | IDO1 (0.48) | TLR8HSD17B1HSD17B2IDO1ESR2 | |
| SCHEMBL13678995 | 0.88 | TLR8 (0.70) | TLR8HSD17B1HSD17B2ESR2APP | |
| SCHEMBL30719598 | 0.86 | HDAC3 (0.53) | TLR8HSD17B1HSD17B2IDO1ESR2 | |
| SCHEMBL30719597 | 0.86 | HDAC3 (0.53) | TLR8HSD17B1HSD17B2IDO1ESR2 | |
| SCHEMBL23496971 | 0.86 | HDAC3 (0.53) | TLR8HSD17B1HSD17B2IDO1ESR2 | |
| SCHEMBL17753429 | 0.84 | LMNA (0.56) | TLR8HSD17B1HSD17B2IDO1ESR2 | |
| SCHEMBL22078735 | 0.84 | TLR8 (0.74) | TLR8HSD17B1HSD17B2ESR2APP | |
| SCHEMBL30719615 | 0.84 | TLR8 (0.74) | TLR8HSD17B1HSD17B2ESR2APP | |
| SCHEMBL23496933 | 0.83 | TLR8 (0.52) | TLR8HSD17B1HSD17B2IDO1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | claimed |
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-117586191-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-111542515-B | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2023-12-05 | — | — | CN | disclosed |