Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23496977 | 1.00 | ADORA2A (0.57) | ADORA2ACAMKK1CAMKK2TLR8ESR2 | |
| SCHEMBL23310408 | 0.81 | MAP4K4 (0.59) | ADORA2ACAMKK1CAMKK2GRM4PIK3CD | |
| SCHEMBL23259465 | 0.78 | ADORA2A (0.67) | ADORA2ACAMKK1CAMKK2GRM4PIK3CD | |
| SCHEMBL29986490 | 0.78 | ADORA2A (0.72) | ADORA2ACAMKK1CAMKK2GRM4PIK3CD | |
| SCHEMBL12357140 | 0.78 | ADORA2A (0.72) | ADORA2ACAMKK1CAMKK2GRM4PIK3CD | |
| SCHEMBL27739446 | 0.78 | ADORA2A (0.72) | ADORA2ACAMKK1CAMKK2GRM4PIK3CD | |
| SCHEMBL28872934 | 0.78 | ADORA2A (0.66) | ADORA2ACAMKK1CAMKK2GRM4HSD17B1 | |
| SCHEMBL29986457 | 0.78 | ADORA2A (0.66) | ADORA2ACAMKK1CAMKK2GRM4HSD17B1 | |
| SCHEMBL29987357 | 0.78 | ADORA2A (0.66) | ADORA2ACAMKK1CAMKK2GRM4PIK3CD | |
| SCHEMBL28872932 | 0.78 | ADORA2A (0.66) | ADORA2ACAMKK1CAMKK2GRM4PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | claimed |
| CN-117586191-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-111542515-B | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2023-12-05 | — | — | CN | disclosed |