Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 13/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3070946 | 0.93 | REN (0.44) | NPC1APOBEC3ARAB9AAPOBEC3GREN | |
| SCHEMBL3072693 | 0.93 | REN (0.51) | NPC1APOBEC3ARAB9AAPOBEC3GREN | |
| SCHEMBL3079274 | 0.93 | REN (0.45) | NPC1APOBEC3ARAB9AAPOBEC3GREN | |
| SCHEMBL3420312 | 0.92 | NPC1 (0.45) | NPC1APOBEC3ARAB9AAPOBEC3GREN | |
| SCHEMBL3067113 | 0.92 | REN (0.44) | NPC1APOBEC3ARAB9AAPOBEC3GREN | |
| SCHEMBL3071132 | 0.89 | REN (0.46) | REN | |
| SCHEMBL3069431 | 0.89 | REN (0.43) | REN | |
| SCHEMBL3070960 | 0.89 | REN (0.44) | REN | |
| SCHEMBL3072870 | 0.89 | REN (0.44) | REN | |
| SCHEMBL3072385 | 0.89 | REN (0.45) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842688-B2 | Organic compounds | NOVARTIS PHARMA AG (CH) | 2010-11-30 | — | — | US | disclosed |
| US-7790715-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-09-07 | — | — | US | disclosed |
| US-20090012055-A1 | Organic compounds | HEROLD PETER | 2009-01-08 | — | — | US | disclosed |
| US-20070010511-A1 | Organic compounds | NOVARTIS PHARMA AG (CH) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012055-A1 | Organic compounds | REN, ACE, ACE2 | NPC1 794/4885APOBEC3A 4608/4885RAB9A 1066/4885 |
| US-20070010511-A1 | Organic compounds | REN, ACE, ACE2 | NPC1 794/4885APOBEC3A 4608/4885RAB9A 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.