Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 4/20 | 0.50 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 16/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24717747 | 1.00 | IKZF2 (0.50) | IKZF2IKZF1CRBNESR1DDB1 | |
| SCHEMBL29132153 | 0.96 | IKZF2 (0.51) | IKZF2IKZF1CRBNESR1DDB1 | |
| SCHEMBL29928051 | 0.96 | IKZF2 (0.51) | IKZF2IKZF1CRBNESR1DDB1 | |
| SCHEMBL25134214 | 0.96 | IKZF2 (0.51) | IKZF2IKZF1CRBNESR1DDB1 | |
| SCHEMBL31160690 | 0.90 | CRBN (0.57) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL29596179 | 0.90 | CRBN (0.57) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL29641124 | 0.90 | CRBN (0.57) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL20046182 | 0.90 | CRBN (0.57) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL22536049 | 0.90 | CRBN (0.57) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL26609341 | 0.89 | CRBN (0.53) | IKZF2IKZF1CRBNESR1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118388454-A | Modulators of BCL6 proteolysis and related methods of use | 阿尔维纳斯运营股份有限公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-4323352-A1 | MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |