Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26957673 | 1.00 | EGFR (0.39) | EGFRPIK3CAMAT2APRNPPPARG | |
| SCHEMBL30784552 | 0.95 | GAA (0.38) | EGFRPIK3CAMAT2APRNPPPARG | |
| SCHEMBL30866157 | 0.91 | PIK3CA (0.41) | EGFRPIK3CADDR1 | |
| SCHEMBL30564404 | 0.84 | EGFR (0.39) | EGFRPIK3CAMAT2APRNPPPARG | |
| SCHEMBL30866135 | 0.83 | KMT2A (0.45) | EGFRPIK3CAGAAALOX15HSD17B10 | |
| SCHEMBL30564366 | 0.79 | SMN1; SMN2 (0.41) | EGFRPIK3CAHTTNPSR1DDR1 | |
| SCHEMBL30564444 | 0.79 | DDR1 (0.37) | EGFRPIK3CAPRNPPPARGHTT | |
| SCHEMBL25360881 | 0.79 | EGFR (0.43) | EGFRPRNPPPARGHTTNCOA2 | |
| SCHEMBL30336004 | 0.79 | EGFR (0.43) | EGFRPRNPPPARGHTTNCOA2 | |
| SCHEMBL15229032 | 0.78 | ALOX15 (0.38) | PIK3CAMAT2ANPSR1GAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026424-A1 | QUINAZOLINONE DERIVATIVES AS AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| WO-2024000401-A1 | 2-((1-(6-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-8-YL)ETHYL)AMINO)BENZOIC ACID DERIVATIVES AND SIMILAR COMPOUNDS AS PI3K INHIBITORS FOR THE TREATMENT OF E.G. CANCER | QILU REGOR THERAPEUTICS INC. (CN) | 2024-01-04 | — | — | WO | disclosed |