Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 10/20 | 0.35 |
| ▸ | RET | P07949 | 4/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | PIP5K1C | O60331 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18812844 | 1.00 | ITK (0.35) | ITKRETKDRIDH1MEN1 | |
| SCHEMBL29199694 | 0.96 | ITK (0.36) | ITKRETKDR | |
| SCHEMBL24670034 | 0.88 | ITK (0.36) | ITKRETKDRABL1 | |
| SCHEMBL30801249 | 0.88 | ITK (0.36) | ITKRETKDRABL1 | |
| SCHEMBL24671283 | 0.84 | RET (0.33) | ITKRETKDRABL1 | |
| SCHEMBL24670121 | 0.84 | RET (0.33) | ITKRETKDRABL1 | |
| SCHEMBL29990667 | 0.84 | RET (0.33) | ITKRETKDRABL1 | |
| SCHEMBL29199673 | 0.83 | ITK (0.37) | ITKRETKDR | |
| SCHEMBL24671810 | 0.80 | RET (0.33) | ITKRETKDR | |
| SCHEMBL30863352 | 0.79 | RET (0.32) | ITKRETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117916231-A | Compounds for inhibiting or degrading target proteins, compositions comprising the same, methods of making and methods of using the same | 纽力克斯治疗公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-110845482-B | Process for preparing indole compounds | 日本烟草产业株式会社 | 2024-01-19 | — | — | CN | disclosed |