Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 6/20 | 0.35 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | HCK | P08631 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670034 | 1.00 | ITK (0.36) | ITKRETKDRPIK3CDGAA | |
| SCHEMBL29199673 | 0.95 | ITK (0.37) | ITKRETKDRPIK3CD | |
| SCHEMBL18812844 | 0.88 | ITK (0.35) | ITKRETKDRABL1 | |
| SCHEMBL30721389 | 0.88 | ITK (0.35) | ITKRETKDRABL1 | |
| SCHEMBL29199694 | 0.83 | ITK (0.36) | ITKRETKDR | |
| SCHEMBL30721387 | 0.79 | ITK (0.56) | ITK | |
| SCHEMBL18812845 | 0.79 | ITK (0.56) | ITK | |
| SCHEMBL30066235 | 0.78 | HRH3 (0.38) | ITKRETKDRPIK3CA | |
| SCHEMBL24670026 | 0.78 | HRH3 (0.38) | ITKRETKDRPIK3CA | |
| SCHEMBL24670814 | 0.74 | ITK (0.45) | ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117916231-A | Compounds for inhibiting or degrading target proteins, compositions comprising the same, methods of making and methods of using the same | 纽力克斯治疗公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |