Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | LYN | P07948 | 2/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | MARK3 | P27448 | 2/20 | 0.44 |
| ▸ | BLK | P51451 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20089759 | 1.00 | KDR (0.44) | KDRLCKCSF1RFGFR1ROCK1 | |
| SCHEMBL28919844 | 0.79 | PDPK1 (0.46) | KDRLCKCSF1RFGFR1ROCK1 | |
| SCHEMBL24455090 | 0.76 | MAPK1 (0.51) | KDRLCKCSF1RFGFR1ROCK1 | |
| SCHEMBL10076075 | 0.76 | KDR (0.47) | KDRLCKCSF1RFGFR1ROCK1 | |
| SCHEMBL16724833 | 0.76 | PDPK1 (0.47) | KDRLCKCSF1RFGFR1ROCK1 | |
| SCHEMBL6830412 | 0.76 | PDPK1 (0.43) | KDRLCKCSF1RFGFR1ROCK1 | |
| SCHEMBL30566149 | 0.76 | PDPK1 (0.61) | KDRLCKCSF1RFGFR1ROCK1 | |
| SCHEMBL23604563 | 0.76 | PDPK1 (0.52) | KDRLCKCSF1RFGFR1ROCK1 | |
| SCHEMBL760018 | 0.76 | PDPK1 (0.61) | KDRLCKCSF1RFGFR1ROCK1 | |
| SCHEMBL15265673 | 0.76 | HTR1A (0.37) | KDRLCKCSF1RFGFR1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006776-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND MEDICAL USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |