Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 4/20 | 0.57 |
| ▸ | CDK7 | P50613 | 3/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.57 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.57 |
| ▸ | CCNH | P51946 | 1/20 | 0.57 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29174705 | 1.00 | CDK9 (0.57) | CDK9CDK7CSNK1A1CCNT1CSNK1D | |
| SCHEMBL29174577 | 0.88 | CDK9 (0.51) | CDK9CDK7CSNK1A1CCNT1CSNK1D | |
| SCHEMBL29174605 | 0.85 | JAK3 (0.55) | CDK9CDK7CSNK1A1CCNT1CSNK1D | |
| SCHEMBL30725499 | 0.79 | HDAC3 (0.47) | CDK9CDK7CCNT1HDAC3HDAC1 | |
| SCHEMBL29174688 | 0.79 | HDAC3 (0.47) | CDK9CDK7CCNT1HDAC3HDAC1 | |
| SCHEMBL29174645 | 0.77 | HDAC3 (0.55) | CDK9HDAC3HDAC1HDAC6KDR | |
| SCHEMBL30725550 | 0.77 | HDAC3 (0.55) | CDK9HDAC3HDAC1HDAC6KDR | |
| SCHEMBL29174703 | 0.77 | EGFR (0.55) | CDK9CDK7CCNHHDAC3HDAC1 | |
| SCHEMBL30725437 | 0.77 | HDAC3 (0.51) | CDK9CDK7CCNT1HDAC3HDAC1 | |
| SCHEMBL29174734 | 0.77 | HDAC3 (0.51) | CDK9CDK7CCNT1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117430589-A | 2-aminopyrimidine compound or salt thereof, and preparation method and application thereof | 励缔(杭州)医药科技有限公司 | 2024-01-23 | — | — | CN | disclosed |