Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.74 |
| ▸ | TSHR | P16473 | 3/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.51 |
| ▸ | NPY2R | P49146 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30163245 | 0.97 | ALDH1A1 (0.79) | ALDH1A1TSHRTDP1LMNAADRB2 | |
| SCHEMBL39110 | 0.97 | ALDH1A1 (0.79) | ALDH1A1TSHRTDP1LMNAADRB2 | |
| SCHEMBL14763796 | 0.97 | ALDH1A1 (0.79) | ALDH1A1TSHRTDP1LMNAADRB2 | |
| SCHEMBL27959032 | 0.95 | ALDH1A1 (0.77) | ALDH1A1TSHRTDP1LMNAADRB2 | |
| SCHEMBL1282666 | 0.88 | ALDH1A1 (0.62) | ALDH1A1TSHRTDP1LMNAADRB2 | |
| SCHEMBL1282669 | 0.88 | ALDH1A1 (0.62) | ALDH1A1TSHRTDP1LMNAADRB2 | |
| SCHEMBL5312448 | 0.88 | ALDH1A1 (0.66) | ALDH1A1TSHRTDP1LMNAADRB2 | |
| SCHEMBL23904385 | 0.86 | ALDH1A1 (0.64) | ALDH1A1TSHRTDP1LMNAADRB2 | |
| SCHEMBL30136451 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TSHRTDP1LMNAADRB2 | |
| SCHEMBL29387332 | 0.86 | ALDH1A1 (1.00) | ALDH1A1TSHRTDP1LMNAADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114650915-B | Layer structure with modified structure and production thereof | 科思创德国股份有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117677499-A | Specific polymer layers useful for faster lamination of multilayer structures | 科思创德国股份有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-117642290-A | Film structure suitable for rapid lamination | 科思创德国股份有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117203063-A | Method for locally coloring plastic parts using solid dyes in a color carrier layer | 科思创德国股份有限公司 | 2023-12-08 | — | — | CN | disclosed |