SCHEMBL30727129

SCHEMBL30727129

COc1cccc(OC)c1-n1c(NS(=O)(=O)C(C)C(OC)c2ncc(C)cn2)nnc1-c1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
APLNR P35414 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21748027 1.00 APLNR (1.00) APLNR
SCHEMBL18245757 1.00 APLNR (1.00) APLNR
SCHEMBL29219021 1.00 APLNR (1.00) APLNR
SCHEMBL19425864 1.00 APLNR (1.00) APLNR
SCHEMBL18247254 0.94 APLNR (1.00) APLNR
SCHEMBL28452675 0.94 APLNR (1.00) APLNR
SCHEMBL18246985 0.94 APLNR (1.00) APLNR
SCHEMBL20767800 0.94 APLNR (1.00) APLNR
SCHEMBL18247196 0.94 APLNR (1.00) APLNR
SCHEMBL18245666 0.94 APLNR (1.00) APLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4532015-A1 APELIN RECEPTOR MODULATORS FOR TREATMENT OF A DISORDER OR DISEASE ASSOCIATED WITH BBB PERMEABILITY Bioage Labs, Inc. (US) 2025-04-09 EP disclosed
WO-2023235360-A1 APELIN RECEPTOR MODULATORS FOR TREATMENT OF A DISORDER OR DISEASE ASSOCIATED WITH BBB PERMEABILITY BioAge Labs, Inc. (US) 2023-12-07 WO disclosed