SCHEMBL30728184

SCHEMBL30728184

C[C@H]1CCCN(Cc2ccc[nH]2)C1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 1/20 0.47
CCR2 P41597 1/20 0.47
ROCK1 Q13464 1/20 0.47
LMNA P02545 1/20 0.47
DRD2 P14416 1/20 0.47
DRD4 P21917 1/20 0.47
DRD3 P35462 1/20 0.47
CYP3A4 P08684 1/20 0.46
CYP2C19 P33261 1/20 0.46
HRH3 Q9Y5N1 3/20 0.41
GAA P10253 1/20 0.41
KDM4E B2RXH2 1/20 0.41
KMT2A Q03164 2/20 0.40
PARP1 P09874 1/20 0.40
HRH4 Q9H3N8 1/20 0.40
ALDH1A1 P00352 2/20 0.40
MAPK1 P28482 1/20 0.40
MEN1 O00255 1/20 0.39
HPGD P15428 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14197743 0.91 DRD2 (0.49) ROCK2CCR2ROCK1LMNADRD2
SCHEMBL25422208 0.82 CYP2D6 (0.59) ROCK2CCR2ROCK1LMNADRD2
SCHEMBL14375224 0.81 DRD2 (0.55) DRD2DRD4DRD3HRH3PARP1
SCHEMBL7682702 0.78 DRD2 (0.64) ROCK2CCR2ROCK1LMNADRD2
SCHEMBL28770942 0.77 DRD2 (0.62) ROCK2CCR2ROCK1LMNADRD2
SCHEMBL17277375 0.75 KAT2B (0.52) LMNAHRH3KMT2AHRH4
SCHEMBL5304179 0.74 CYP3A4 (0.66) CYP3A4CYP2C19HRH3KDM4EHRH4
SCHEMBL13083 0.74 CYP3A4 (0.66) CYP3A4CYP2C19HRH3KDM4EHRH4
SCHEMBL12717 0.74 CYP3A4 (0.66) CYP3A4CYP2C19HRH3KDM4EHRH4
SCHEMBL3968181 0.74 DRD2 (0.73) ROCK2CCR2ROCK1DRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4558501-A1 CBL-B INHIBITORS AND METHODS OF USE THEREOF Arcus Biosciences, Inc. (US) 2025-05-28 EP disclosed
WO-2024020034-A1 CBL-B INHIBITORS AND METHODS OF USE THEREOF ARCUS BIOSCIENCES, INC. (US) 2024-01-25 WO disclosed