Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | DTYMK | P23919 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21745526 | 1.00 | POLB (0.40) | POLBGPR119DDB1CRBNDTYMK | |
| SCHEMBL21714074 | 0.90 | POLB (0.43) | POLBGPR119DDB1CRBNDTYMK | |
| SCHEMBL21713777 | 0.84 | KEAP1 (0.32) | KEAP1NFE2L2 | |
| SCHEMBL21713421 | 0.83 | ACACB (0.36) | GPR119NR1H2KEAP1NFE2L2 | |
| SCHEMBL21762118 | 0.80 | POLB (0.40) | POLBGPR119DDB1CRBNDTYMK | |
| SCHEMBL21713401 | 0.76 | CA12 (0.33) | MAPTKEAP1 | |
| SCHEMBL21713863 | 0.75 | EPHX2 (0.35) | MAPK1MAPTKEAP1NFE2L2 | |
| SCHEMBL22945801 | 0.75 | POLB (0.43) | POLBGPR119DDB1CRBNDTYMK | |
| SCHEMBL21745091 | 0.74 | POLB (0.43) | POLBGPR119DTYMKMAPK1GRM5 | |
| SCHEMBL21713916 | 0.74 | CA12 (0.32) | KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3833662-B1 | INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | JANSSEN PHARMACEUTICA NV (BE) | 2024-01-17 | — | — | EP | disclosed |