Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.63 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.63 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729324 | 0.82 | CRBN (0.52) | CRBNDDB1IKZF3 | |
| SCHEMBL30720144 | 0.81 | CRBN (0.59) | CRBNDDB1 | |
| SCHEMBL30703621 | 0.80 | CRBN (0.77) | CRBNDDB1NAMPTIKZF3 | |
| SCHEMBL30720114 | 0.79 | CRBN (0.63) | CRBNDDB1 | |
| SCHEMBL27260521 | 0.79 | CRBN (0.63) | CRBNDDB1 | |
| SCHEMBL27238864 | 0.79 | CRBN (0.63) | CRBNDDB1 | |
| SCHEMBL31382134 | 0.78 | CRBN (0.63) | CRBNDDB1 | |
| SCHEMBL21965433 | 0.77 | DDB1 (1.00) | CRBNDDB1 | |
| SCHEMBL24481327 | 0.77 | CRBN (0.58) | CRBNDDB1 | |
| SCHEMBL29579057 | 0.77 | CRBN (0.58) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260007681-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | UNIV MICHIGAN (US) | 2026-01-08 | — | — | US | disclosed |
| WO-2024015406-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260007681-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ESRRA, ESR2, AR | CRBN 570/4885DDB1 2677/4885MAP3K5 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.