Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729282 | 0.82 | CRBN (0.63) | CRBNDDB1IKZF3 | |
| Hydrochloric Acid SCHEMBL30729392 | 0.78 | CRBN (0.56) | CRBNDDB1IKZF3SMYD3BRD4 | |
| SCHEMBL31731804 | 0.72 | CRBN (0.63) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL20812494 | 0.72 | CRBN (0.67) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL24890982 | 0.72 | CRBN (0.66) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL21946811 | 0.72 | CRBN (0.67) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL30659854 | 0.72 | CRBN (0.66) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL24491253 | 0.72 | CRBN (0.66) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL20128680 | 0.72 | CRBN (0.66) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL25567227 | 0.72 | CRBN (0.66) | CRBNDDB1IKZF3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260007681-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | UNIV MICHIGAN (US) | 2026-01-08 | — | — | US | disclosed |
| WO-2024015406-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260007681-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ESRRA, ESR2, AR | CRBN 570/4885DDB1 2677/4885IKZF3 2581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.